Endocrine Abstracts

Objective: to evaluate the effects of metformin use on weight loss, improvement of ovarian and thyroid function in obese women with polycystic ovarian syndrome.Material and Methods: 30 obese (BMI 30–34.99 kg/m2) hypothyroid (TSH 6–10 mIU/ml) women of age 25–35 years old were included. The patients received appropriate levothyroxine treatment according to TSH levels and body weight. A number of 15 patients added metformin gradual...

Introduction: Parathyroid adenomas are the main cause of primary hyperparathyroidism. They are usually small – weighing <1 g – and not easy to find – requiring meticulous imaging studies for localisation. Giant adenomas are uncommon; large tumours and high levels of PTH raise the suspicion of parathyroid malignancy.Case presentation: A 68-year-old female presented in our clinic with polydipsia, poliuria, nausea, weight loss, and extrem...

Background: Polycystic ovarian syndrome (PCOS) diagnosis is set based on Rotterdam criteria, including hyperandrogenism, chronic anovulation and typical ultrasound appearance. 65–70% of women with PCOS have insulin resistance. Metformin, an oral antidiabetic agent, was the first drug used to treat insulin resistance in PCOS patients.Material and method: Twenty non-diabetic women between 25–35 years old, with PCOS untreated prior to presentation...

Some patients with type 2 diabetes mellitus (T2DM) suffer from severe acquired insulin resistance (IR). There is still a shortage of research analyzing the T2DM patients with severe IR and identifying their risk factors.Aim: To evaluate how selected sociodemographic and metabolic factors are linked to severe IR among patients with T2DM.Methods: It was a case control study. If T2DM patients received high insulin doses (>1 IU/kg/...

Introduction: Fractionated stereotactic radiotherapy (FSRT) is used in the treatment of surgically inaccessible meningiomas, primarily in the base of the skull. Development of hypopituitarism following FSRT is inexhaustively investigated. We aimed to elucidate the cause of hypopituitarism in patients treated with FSRT for benign meningiomas of the anterior skull base.Methods: All patients undergoing FSRT for benign meningioma of the skull base between Ju...

Introduction: Acromegaly is a chronic disease with a serious impact on patients’ morbidity, mortality and health-related quality of life (HRQOL). Recently a disease-specific questionnaire assessing HRQOL in acromegaly was developed (AcroQoL). Using this tool we have compared QoL in patients with controlled versus uncontrolled acromegaly.Patients and methods: It was a prospective, cross-sectional study. For the period 2007–December 2008 163 pati...

We present the case of a 51 years old woman, nonsmoker, without relevant past medical history, who presented with acute psychotic state starting the third day of treatment with prednisone 30 mg indicated for allergy. She had also arterial hypertension and a significant and progressive loss of proximal muscle strength in her legs. The initial evaluation showed hyperglycemia, metabolic alkalosis and severe hypokalemia. Basal plasma cortisol was high (>90 μg/dl) and did ...

There are still many questions remaining about the etiopathogenesis of thyroid cancer, themost common type of endocrine neoplasia. Numerous occupational and environmental exposureshave been shown to represent important risk factors that increase its incidence. Updated informationabout thyroid cancer diagnostics related to occupational and environmental risk factors is reviewedhere, considering an integrated risk assessment approach; new data concerning thyroid canceretiology a...

Background: BCL-2 is an anti-apoptotic protein associated with resistance to tumor cell death and is a histopathologic marker of neuroendocrine differentiation. We characterized the transcriptomic profile of BCL2 expression in NENs and its association with site, immune infiltration, and overall survival (OS).Methods: Next-generation sequencing of both DNA (592-gene panel or whole exome) and RNA (whole transcriptome) was performed on NENs of pancreatic (P...

Background: Insulin pump therapy is an alternative to multiple daily injections and can improve glycemic control and quality of life (QoL) in Type 1 diabetes mellitus (T1DM) patients. The aim of this study was to assess the differences and factors related to the T1DM-specific QoL of T1DM patients in Latvia.Methods: 87 adult patients with T1DM were included. Of them, 20 were pump users and 67 were users of injections. All recruited patients participated i...